Mabuterol free base

Description: Mabuterol is a selective agonist of beta2 adrenoreceptor with no beta 1-stimulation. Mabuterol inhibited the positive inotropic effect of isoprenaline at 10(-7) g/ml and decreased the maximum driving frequency at 3 X 10(-6) g/ml. Mabuterol was 3 times more potent in relaxing the isolated rat uterus, but 700 times less potent than isoprenaline in relaxing the rabbit jejunum. Mabuterol (p.o.) depressed the intestinal propulsion and was equipotent to isoprenaline and 2.5 times less potent than salbutamol. Target: Others. Smiles: FC(F)(F)C1=CC(=CC(Cl)=C1N)C(O)CNC(C)(C)C. References: Song X, Zhao C, Dai C, Ren Y, An N, Wen H, Pan LI, Cheng M, Zhang Y. Suppression of the increasing level of acetylcholine-stimulated intracellular Ca(2+) in guinea pig airway smooth muscle cells by mabuterol. Biomed Rep. 2015 Nov,3(6):778-786. Epub 2015 Aug 4. PubMed PMID: 26623015, PubMed Central PMCID: PMC4660599.