M2698

M2698 is a dual inhibitor of p70 ribosomal S6 kinase (p70S6K) and Akt1 (IC50s = 1.1 and 4 nM, respectively). It is selective for p70S6K and Akt1 over Aurora B kinase (IC50 = 170 nM), as well as a panel of 265 kinases at 1 µM, but also inhibits protein kinase A (PKA), p90 ribosomal S6 kinase 1 (MSK1), MSK2, cGMP-dependent protein kinase 1alpha (PKG1alpha), PKG1beta, and protein kinase X (PRKX). M2698 reduces tumor volume in MiaPaCa-2 pancreatic cancer and A549 non-small cell lung cancer (NSCLC) mouse xenograft models when administered at doses of 20 or 30 mg/kg, respectively.Formal Name: 4-[[(1S)-2-(1-azetidinyl)-1-[4-chloro-3-(trifluoromethyl)phenyl]ethyl]amino]-8-quinazolinecarboxamide. CAS Number: 1379545-95-5. Synonyms: MSC2363318A. Molecular Formula: C21H19ClF3N5O. Formula Weight: 449.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: FC(F)(F)C(C=C1[C@@H](CN2CCC2)NC3=NC=NC4=C3C=CC=C4C(N)=O)=C(C=C1)Cl. InChi Code: InChI=1S/C21H19ClF3N5O/c22-16-6-5-12(9-15(16)21(23,24)25)17(10-30-7-2-8-30)29-20-14-4-1-3-13(19(26)31)18(14)27-11-28-20/h1,3-6,9,11,17H,2,7-8,10H2,(H2,26,31)(H,27,28,29)/t17-/m1/s1. InChi Key: HXAUJHZZPCBFPN-QGZVFWFLSA-N.