LY379268

LY379268 is a potent, brain-permeable, and selective agonist of group II metabotropic glutamate receptors (mGluRs), subtypes mGluR2 and mGluR3. In an assay of second messenger response, LY379268 exhibits EC50 values of 2.69 and 4.48 nM for human mGluR2 and mGluR3, respectively, with at least 80-fold selectivity over group I and III mGluRs. In a displacement assay, LY379268 displays no agonist or antagonist activity against NMDA, AMPA, or kainate receptors up to a concentration of 100 µM. However, it may influence the level of AMPA receptor trafficking in rat prefrontal cortical neurons. LY379268 confers a neuroprotective effect to the CA1 of the hippocampus in a gerbil model of induced ischemia at a dose of 10 mg/kg. In rats, LY379268 (3 mg/kg) raises the extracellular dopamine level to 168% of the basal level in the prefrontal cortex.Formal Name: (1R,4R,5S,6R)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid. CAS Number: 191471-52-0. Molecular Formula: C7H9NO5. Formula Weight: 187.2. Purity: >99%. Formulation: (Request formulation change), A solid. Solubility: Water: 25 mM. SMILES: [H][C@]1([C@@H]2C(O)=O)[C@]2([H])[C@@](C(O)=O)(N)CO1. InChi Code: InChI=1S/C7H9NO5/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1. InChi Key: YASVRZWVUGJELU-MDASVERJSA-N.