LY3295668

LY3295668 is an inhibitor of Aurora A kinase (IC50 = 2 phase in HeLa cells (IC50 = 108 nM). In vivo, LY3295668 (40 mg/kg per day) decreases tumor volume in a patient-derived xenograft (PDX) mouse model of small cell lung cancer.Formal Name: (2R,4R)-1-[(3-chloro-2-fluorophenyl)methyl]-4-[[3-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]-2-methyl-4-piperidinecarboxylic acid. CAS Number: 1919888-06-4. Synonyms: AK-01. Molecular Formula: C24H26ClF2N5O2. Formula Weight: 490.0. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly soluble: 0.1-1 mg/ml, Ethanol: Sparingly soluble: 1-10 mg/ml, Water: Slightly soluble: 0.1-1 mg/ml. SMILES: ClC1=CC=CC(CN2[C@H](C)C[C@](CC3=C(F)C=CC(NC4=NNC(C)=C4)=N3)(C(O)=O)CC2)=C1F. InChi Code: InChI=1S/C24H26ClF2N5O2/c1-14-10-21(31-30-14)29-20-7-6-18(26)19(28-20)12-24(23(33)34)8-9-32(15(2)11-24)13-16-4-3-5-17(25)22(16)27/h3-7,10,15H,8-9,11-13H2,1-2H3,(H,33,34)(H2,28,29,30,31)/t15-,24-/m1/s1. InChi Key: YQQZZYYQTCPEAS-OYLFLEFRSA-N.