LY3200882

LY3200882 is an ATP-competitive inhibitor of TGF-beta receptor type 1 (TGF-betaRI). It inhibits TGF-beta-induced SMAD phosphorylation in vitro and in vivo and exhibits antitumor activity in the 4T1-LP triple negative breast cancer orthotopic tumor model.Formal Name: 4-[[4-[[1-cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]oxy]-2-pyridinyl]amino]-alpha,alpha-dimethyl-2-pyridinemethanol. CAS Number: 1898283-02-7. Molecular Formula: C24H29N5O3. Formula Weight: 435.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. lambdamax: 294 nm. SMILES: CC(O)(C)C1=CC(NC2=NC=CC(OC3=CN(C4CC4)N=C3C5CCOCC5)=C2)=CC=N1. InChi Code: InChI=1S/C24H29N5O3/c1-24(2,30)21-13-17(5-9-25-21)27-22-14-19(6-10-26-22)32-20-15-29(18-3-4-18)28-23(20)16-7-11-31-12-8-16/h5-6,9-10,13-16,18,30H,3-4,7-8,11-12H2,1-2H3,(H,25,26,27). InChi Key: PNPFMWIDAKQFPY-UHFFFAOYSA-N.