LY315920

LY315920 is an inhibitor of human group IIA (hGIIA) secretory phospholipase A2 (sPLA2, IC50 = 9 nM). It also potently inhibits human GIIE and GX isoforms, as well as the corresponding mouse isoforms, but poorly inhibits other PLA2 enzymes. LY315920 inhibits sPLA2-induced release of thromboxane A2 from isolated guinea pig lung bronchoalveolar lavage cells (IC50 = 0.79 µM). Intravenous or oral administration of LY315920 to transgenic mice expressing human sPLA2 inhibits serum sPLA2 activity in a dose-related manner over four hours.Formal Name: 2-[[3-(2-amino-2-oxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]-acetic acid. CAS Number: 172732-68-2. Synonyms: Varespladib. Molecular Formula: C21H20N2O5. Formula Weight: 380.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 3 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 217, 256, 331 nm. SMILES: O=C(O)COC1=C2C(N(CC3=CC=CC=C3)C(CC)=C2C(C(N)=O)=O)=CC=C1. InChi Code: InChI=1S/C21H20N2O5/c1-2-14-19(20(26)21(22)27)18-15(9-6-10-16(18)28-12-17(24)25)23(14)11-13-7-4-3-5-8-13/h3-10H,2,11-12H2,1H3,(H2,22,27)(H,24,25). InChi Key: BHLXTPHDSZUFHR-UHFFFAOYSA-N.