LY3000328

LY3000328 is a potent cathepsin S inhibitor (IC50 = 7.7 nM for the human enzyme). It is selective for cathepsin S over cathepsin L, K, B, and V (IC50s = >10,000, >10,000, 4,390, and 21,500 nM, respectively). LY3000328 (1-30 mg/kg) reduces aortic diameter in a mouse model of calcium chloride-induced abdominal aortic aneurysm.Formal Name: N-[(3R,4S)-3,4-dihydro-3-[[(methylamino)carbonyl]oxy]-6-[4-(3-oxetanyl)-1-piperazinyl]-2H-1-benzopyran-4-yl]-4-fluoro-benzamide. CAS Number: 1373215-15-6. Molecular Formula: C25H29FN4O5. Formula Weight: 484.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.50 mg/ml. lambdamax: 235 nm. SMILES: C=C(C1=CC=C(C)C=C1)C[C@@H]2[C@@H](CC(CC)=C)CCC3=CC=C(C4CCC(C5CCC5)CC4)C=C32. InChi Code: InChI=1S/C35H46/c1-5-24(2)21-33-20-18-31-17-19-32(30-15-13-29(14-16-30)28-7-6-8-28)23-35(31)34(33)22-26(4)27-11-9-25(3)10-12-27/h9-12,17,19,23,28-30,33-34H,2,4-8,13-16,18,20-22H2,1,3H3/t29?,30?,33-,34-/m1/s1. InChi Key: YTWOSVWRJQCECI-YUVTWRQCSA-N.