LY2119620

LY2119620 is a positive allosteric modulator of the M2 and M4 muscarinic acetylcholine receptors (mAChRs). It binds to allosteric sites on M2 and M4 receptors with KB values ranging from 1.8 to 3.4 µM. LY2119620 potentiates the activity of the AChR agonist acetylcholine (ACh, Cay-23829) and the mAChR agonists iperoxo and oxotremorine M (Cay-20847) at human recombinant M2 and M4 receptors expressed in CHO cell membranes. LY2119620 also exhibits allosteric agonism at M2 and M4 receptors (23.2 and 16.8%, respectively, of the maximal ACh response).Formal Name: 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]-thieno[2,3-b]pyridine-2-carboxamide. CAS Number: 886047-22-9. Molecular Formula: C19H24ClN5O3S. Formula Weight: 437.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml, Ethanol: 1 mg/ml. lambdamax: 291 nm. SMILES: CN1CCN(C(COC2=NC(SC(C(NC3CC3)=O)=C4N)=C4C(C)=C2Cl)=O)CC1. InChi Code: InChI=1S/C19H24ClN5O3S/c1-10-13-15(21)16(17(27)22-11-3-4-11)29-19(13)23-18(14(10)20)28-9-12(26)25-7-5-24(2)6-8-25/h11H,3-9,21H2,1-2H3,(H,22,27). InChi Key: TYTGOXSAAQWLPJ-UHFFFAOYSA-N.