LXR-623

LXR-623 is a liver X receptor (LXR) modulator that acts as a partial agonist at LXRalpha and a full agonist at LXRbeta (IC50s = 179 and 24 nM, respectively). It is orally bioavailable and readily passes the blood-brain barrier. LXR-623 is anti-atherogenic in animal models of atherosclerosis, showing synergistic effects when combined with simvastatin (Cay-10010344, Cay-10010345).Formal Name: 2-[(2-chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole. CAS Number: 875787-07-8. Synonyms: WAY-252623. Molecular Formula: C21H12ClF5N2. Formula Weight: 422.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/mL, DMSO: 30 mg/mL, Ethanol: 30 mg/mL, Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/mL. lambdamax: 209, 318 nm. SMILES: FC(C=C1)=CC=C1C2=C3C(C(C(F)(F)F)=CC=C3)=NN2CC4=CC=C(F)C=C4Cl. InChi Code: InChI=1S/C21H12ClF5N2/c22-18-10-15(24)9-6-13(18)11-29-20(12-4-7-14(23)8-5-12)16-2-1-3-17(19(16)28-29)21(25,26)27/h1-10H,11H2. InChi Key: KYWWJENKIMRJBI-UHFFFAOYSA-N.