LXH254

LXH254 is a pan-RAF inhibitor that selectively inhibits B-RAF and C-RAF over a panel of 456 human kinases. It inhibits MAPK signaling in tumor cells expressing mutant B-RAFV600. LXH254 induces tumor regression in various mouse xenograft models.Formal Name: N-[3-[2-(2-hydroxyethoxy)-6-(4-morpholinyl)-4-pyridinyl]-4-methylphenyl]-2-(trifluoromethyl)-4-pyridinecarboxamide. CAS Number: 1800398-38-2. Molecular Formula: C25H25F3N4O4. Formula Weight: 502.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 250, 305 nm. SMILES: OCCOC1=NC(N2CCOCC2)=CC(C3=CC(NC(C4=CC(C(F)(F)F)=NC=C4)=O)=CC=C3C)=C1. InChi Code: InChI=1S/C25H25F3N4O4/c1-16-2-3-19(30-24(34)17-4-5-29-21(12-17)25(26,27)28)15-20(16)18-13-22(32-6-9-35-10-7-32)31-23(14-18)36-11-8-33/h2-5,12-15,33H,6-11H2,1H3,(H,30,34). InChi Key: UEPXBTCUIIGYCY-UHFFFAOYSA-N.