Lusutrombopag

Lusutrombopag
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay26533-1 1 mg -

6 - 10 business days*

61.00€
Cay26533-5 5 mg -

6 - 10 business days*

266.00€
Cay26533-10 10 mg -

6 - 10 business days*

471.00€
Cay26533-50 50 mg -

6 - 10 business days*

1,461.00€
 
Lusutrombopag is an agonist of the thrombopoietin receptor. It induces proliferation of Ba/F3... more
Product information "Lusutrombopag"
Lusutrombopag is an agonist of the thrombopoietin receptor. It induces proliferation of Ba/F3 cells expressing human MPL, the gene for the thrombopoietin receptor, with an EC50 value of 84 nM but not of those expressing mouse Mpl. Lusutrombopag (0.3-10 mg/kg per day) increases the number of circulating platelets in a transgenic mouse model expressing human MPL and increases the number of megakaryocytes in the bone marrow when administered at a dose of 10 mg/kg per day. Formulations containing lusutrombopag have been used in the treatment of thrombocytopenia in adult patients with chronic liver disease scheduled to undergo invasive procedures.Formal Name: (2E)-3-[2,6-dichloro-4-[[[4-[3-[(1S)-1-(hexyloxy)ethyl]-2-methoxyphenyl]-2-thiazolyl]amino]carbonyl]phenyl]-2-methyl-2-propenoic acid. CAS Number: 1110766-97-6. Molecular Formula: C29H32Cl2N2O5S. Formula Weight: 591.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 30 mg/ml. lambdamax: 218, 260, 322 nm. SMILES: ClC1=C(/C=C(C)/C(O)=O)C(Cl)=CC(C(NC2=NC(C3=CC=CC([C@H](C)OCCCCCC)=C3OC)=CS2)=O)=C1. InChi Code: InChI=1S/C29H32Cl2N2O5S/c1-5-6-7-8-12-38-18(3)20-10-9-11-21(26(20)37-4)25-16-39-29(32-25)33-27(34)19-14-23(30)22(24(31)15-19)13-17(2)28(35)36/h9-11,13-16,18H,5-8,12H2,1-4H3,(H,35,36)(H,32,33,34)/b17-13+/t18-/m0/s1. InChi Key: NOZIJMHMKORZBA-KJCUYJGMSA-N.
Keywords: (2E)-3-[2,6-dichloro-4-[[[4-[3-[(1S)-1-(hexyloxy)ethyl]-2-methoxyphenyl]-2-thiazolyl]amino]carbonyl]phenyl]-2-methyl-2-propenoic acid
Supplier: Cayman Chemical
Supplier-Nr: 26533

Properties

Application: Thrombopoietin receptor agonist
MW: 591.5 D
Formula: C29H32Cl2N2O5S
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 1110766-97-6| Matching products
KEGG ID : K05082 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302, H315, H319, H335
P Phrases: P261, P264, P270, P271, P280, P312, P321, P330, P301+P310, P302+P352, P304+P340, P305+P351+P338, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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