Lumacaftor
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Lumacaftor (VRT 826809) is a CFTR modulator that corrects the folding and... more
Product information "Lumacaftor"
Description: Lumacaftor (VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein. It enhances F508del-CFTR protein maturation in FRT cells (EC50: 100 nM). Target: CFTR, Autophagy. Smiles: Cc1ccc(NC(=O)C2(CC2)c2ccc3OC(F)(F)Oc3c2)nc1-c1cccc(c1)C(O)=O. References: Van Goor F, et al. Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809. Proc Natl Acad Sci U S A. 2011 Nov 15,108(46):18843-8.
| Keywords: | VX-809, VRT 826809 |
| Supplier: | TargetMol |
| Supplier-Nr: | T2595 |
Properties
| Application: | Targets cystic fibrosis transmembrane conductance regulator [EC:5.6.1.6] (CFTR, ABCC7) |
| MW: | 452.41 D |
| Formula: | C24H18F2N2O5 |
Database Information
| CAS : | 936727-05-8| Matching products |
| KEGG ID : | K05031 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H372 |
| P Phrases: | P260, P264, P270, P314, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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