LTI-291

LTI-291 is a CNS-penetrant allosteric activator of glucocerebrosidase (GCase). It increases the activity of wild-type human GCase by 25 and 130% when used at concentrations of 0.1 and 1 µM, respectively.Formal Name: 5,7-dimethyl-N-[trans-4-(pentyloxy)cyclohexyl]-pyrazolo[1,5-a]pyrimidine-3-carboxamide. CAS Number: 1919820-28-2. Molecular Formula: C20H30N4O2. Formula Weight: 358.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 20 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/ml. lambdamax: 224, 238 nm. SMILES: CCCCCO[C@@H](CC1)CC[C@H]1NC(C2=C(N=C(C)C=C3C)N3N=C2)=O. InChi Code: InChI=1S/C20H30N4O2/c1-4-5-6-11-26-17-9-7-16(8-10-17)23-20(25)18-13-21-24-15(3)12-14(2)22-19(18)24/h12-13,16-17H,4-11H2,1-3H3,(H,23,25)/t16-,17-. InChi Key: HZILSILAELSWKN-QAQDUYKDSA-N.