LT175

Peroxisome proliferator-activated receptors (PPARs) are activated by fatty acids and eicosanoids as well as antidyslipidemic agents. Among the receptor isotypes, PPARalpha demonstrates a particular role in fatty acid oxidation whereas PPARgamma is known to be involved in adipocyte differentiation and lipid storage. LT175 is a dual PPARalpha/gamma ligand that displays partial agonism toward PPARgamma (EC50s = 0.22, 0.26, and 0.48 µM for hPPARalpha, mPPARalpha, and hPPARgamma, respectively). It exhibits low adipogenic activity in vitro and improves glucose homeostasis in diet-induced insulin resistant mice. LT175 was shown to disrupt the recruitment of coregulators, cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1, to PPARgamma.Formal Name: alphaS-([1,1'-biphenyl]-4-yloxy)-benzenepropanoic acid. CAS Number: 862901-87-9. Molecular Formula: C21H18O3. Formula Weight: 318.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 50 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml, Ethanol: 25 mg/ml. lambdamax: 260 nm. SMILES: O=C(O)[C@H](CC1=CC=CC=C1)OC(C=C2)=CC=C2C3=CC=CC=C3. InChi Code: InChI=1S/C21H18O3/c22-21(23)20(15-16-7-3-1-4-8-16)24-19-13-11-18(12-14-19)17-9-5-2-6-10-17/h1-14,20H,15H2,(H,22,23)/t20-/m0/s1. InChi Key: TZTPJJNNACUQQR-FQEVSTJZSA-N.