LPA2 Antagonist 1

LPA2 antagonist 1 is an antagonist of lysophosphatidic acid receptor 2 (LPA2, IC50 = 17 nM). It is selective for LPA2 over LPA1 and LPA3 (IC50s = >50 µM). LPA2 antagonist 1 inhibits HGF-induced phosphorylation of ERK and proliferation of HCT116 colon cancer cells in a concentration-dependent manner.Formal Name: N-[(1S)-2-[4-[(3,4-dichlorophenyl)sulfonyl]-1-piperazinyl]-1-methylethyl]-7-methyl-thieno[3,2-d]pyrimidin-4-amine. CAS Number: 1017606-66-4. Synonyms: LPA2-IN-1. Molecular Formula: C20H23Cl2N5O2S2. Formula Weight: 500.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2)(1:2): 0.33 mg/ml. lambdamax: 242, 302 nm. SMILES: ClC1=CC=C(S(N2CCN(C[C@H](C)NC3=NC=NC4=C3SC=C4C)CC2)(=O)=O)C=C1Cl. InChi Code: InChI=1S/C20H23Cl2N5O2S2/c1-13-11-30-19-18(13)23-12-24-20(19)25-14(2)10-26-5-7-27(8-6-26)31(28,29)15-3-4-16(21)17(22)9-15/h3-4,9,11-12,14H,5-8,10H2,1-2H3,(H,23,24,25)/t14-/m0/s1. InChi Key: BPRNMVDTWIHULJ-AWEZNQCLSA-N.