Loxapine-d8

Loxapine-d8 is intended for use as an internal standard for the quantification of loxapine (Cay-20760) by GC- or LC-MS. Loxapine is an atypical antipsychotic. It binds to the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 (Kis = 2,456, 7.7, 9.5, 32, and 87.2 nM, respectively), as well as dopamine D2, histamine H1, and M3 muscarinic acetylcholine receptors (Kis = 12, 7, and 122 nM, respectively). Loxapine also binds to alpha1A-, alpha2A-, alpha2B-, and alpha2C-adrenergic receptors (Kis = 31, 150.8, 107.6, and 79.9 nM, respectively). Formulations containing loxapine have been used in the treatment of schizophrenia.Formal Name: 2-chloro-11-(4-methylpiperazin-1-yl-2,2,3,3,5,5,6,6-d8)dibenzo[b,f][1,4]oxazepine. CAS Number: 1189455-63-7. Molecular Formula: C18H10ClD8N3O. Formula Weight: 335.9. Purity: >99% deuterated forms (d1-d8). Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: soluble, DMSO: soluble, Methanol: soluble. SMILES: ClC1=CC2=C(C=C1)OC3=C(C=CC=C3)N=C2N4C([2H])([2H])C([2H])([2H])N(C)C([2H])([2H])C4([2H])[2H]. InChi Code: InChI=1S/C18H18ClN3O/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3/i8D2,9D2,10D2,11D2. InChi Key: XJGVXQDUIWGIRW-JNJBWJDISA-N.