Losartan Carboxylic Acid

Losartan Carboxylic Acid
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay15957-1 1 mg -

6 - 10 business days*

50.00€
Cay15957-5 5 mg -

6 - 10 business days*

131.00€
Cay15957-10 10 mg -

6 - 10 business days*

216.00€
Cay15957-50 50 mg -

6 - 10 business days*

942.00€
 
Losartan carboxylic acid is an antagonist of the angiotensin II type 1b (AT1b) receptor (Ki =... more
Product information "Losartan Carboxylic Acid"
Losartan carboxylic acid is an antagonist of the angiotensin II type 1b (AT1b) receptor (Ki = 0.67 nM in COS-7 cells expressing the human receptor) and an active metabolite of losartan (Cay-10006594). It is formed from losartan by the cytochrome P450 (CYP) isoform CYP2C9. Losartan carboxylic acid is selective for AT1b over AT2 (Ki = >10,000 nM in COS-7 cells expressing the human receptor). It reduces U-44619-induced aggregation of platelets in isolated human platelet-rich plasma when used at a concentration of 50 µM. Losartan carboxylic acid (1 mg/kg) reduces mean arterial pressure (MAP) in water-deprived rats.Formal Name: 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid. CAS Number: 124750-92-1. Synonyms: E-3174, EXP-3174. Molecular Formula: C22H21ClN6O2. Formula Weight: 436.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 247 nm. SMILES: [H]N1N=NN=C1C2=CC=CC=C2C3=CC=C(CN4C(C(O)=O)=C(Cl)N=C4CCCC)C=C3. InChi Code: InChI=1S/C22H21ClN6O2/c1-2-3-8-18-24-20(23)19(22(30)31)29(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)21-25-27-28-26-21/h4-7,9-12H,2-3,8,13H2,1H3,(H,30,31)(H,25,26,27,28). InChi Key: ZEUXAIYYDDCIRX-UHFFFAOYSA-N.
Keywords: E-3174, EXP-3174, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid
Supplier: Cayman Chemical
Supplier-Nr: 15957

Properties

Application: AGTR1 antagonist
MW: 436.9 D
Formula: C22H21ClN6O2
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 124750-92-1| Matching products
KEGG ID : K04166 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H317, H360, H362
P Phrases: P201, P202, P260, P261, P263, P264, P270, P272, P280, P321, P302+P352, P308+P313, P333+P313, P362+P364, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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