Lomerizine (hydrochloride)

Lomerizine is a voltage-dependent calcium channel blocker that inhibits low- and high-voltage activated calcium currents in rat hippocampal CA1 pyramidal neurons with IC50 values of 1.9 and 4 µM, respectively. It inhibits vasoconstriction induced by potassium chloride, serotonin (5-HT, Cay-14332), or vasopressin in isolated rat basilar arteries when used at a concentration of 1 µM. Lomerizine (1 µM) reduces neurotoxicity induced by glutamate, NMDA, or kainate in rat retinal primary cell cultures. It reduces retinal damage in a rat model of retinal ischemia-reperfusion injury when administered at a dose of 1 mg/kg.Formal Name: 1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]-piperazine, dihydrochloride. CAS Number: 101477-54-7. Synonyms: KB-2796. Molecular Formula: C27H30F2N2O3 . 2HCl. Formula Weight: 541.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 1 mg/ml. SMILES: COC1=CC=C(CN2CCN(C(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)CC2)C(OC)=C1OC.Cl.Cl. InChi Code: InChI=1S/C27H30F2N2O3.2ClH/c1-32-24-13-8-21(26(33-2)27(24)34-3)18-30-14-16-31(17-15-30)25(19-4-9-22(28)10-5-19)20-6-11-23(29)12-7-20,,/h4-13,25H,14-18H2,1-3H3,2*1H. InChi Key: LOGVKVSFYBBUAJ-UHFFFAOYSA-N.