LOC14

LOC14 is an inhibitor of protein disulfide isomerase (PDI, Kd = 62 nM). It inhibits PDI chaperone activity in an insulin aggregation assay when used at a concentration of 75 µM. LOC14 reduces PC12 cell death induced by the misfolded huntingtin protein mHTTQ103 (EC50 = 500 nM). It reduces medium spiny neuron (MSN) degeneration in a rat postnatal cortical brain slice model of mHTTQ73-induced Huntington's disease.Formal Name: 2-[[4-(cyclopropylcarbonyl)-1-piperazinyl]methyl]-1,2-benzisothiazol-3(2H)-one. CAS Number: 877963-94-5. Molecular Formula: C16H19N3O2S. Formula Weight: 317.4. Purity: >90%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10mg/mL, DMF:PBS (pH 7.2) (1:1): 0.5mg/mL, DMSO: 3mg/mL, Ethanol: 3mg/mL, Ethanol:PBS (pH 7.2) (1:6): 0.14mg/mL. lambdamax: 224, 317 nm. SMILES: O=C(C1CC1)N(CC2)CCN2CN3C(C(C=CC=C4)=C4S3)=O. InChi Code: InChI=1S/C16H19N3O2S/c20-15(12-5-6-12)18-9-7-17(8-10-18)11-19-16(21)13-3-1-2-4-14(13)22-19/h1-4,12H,5-11H2. InChi Key: YVBSNHLFRIVWFQ-UHFFFAOYSA-N.