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Product information "LMW-PTP Inhibitor I (hydrochloride)"
LMW-PTP inhibitor I (hydrochloride) is an inhibitor of low molecular weight phosphotyrosine protein phosphatase A (LMW-PTPA, IC50 = 0.8 µM). It is selective for LMW-PTPA over a panel of 15 protein tyrosine phosphatases but does inhibit LMW-PTPB activity by greater than 50% at 40 µM. LMW-PTP inhibitor I (hydrochloride) increases insulin-induced insulin receptor phosphorylation in HepG2 cells when used at a concentration of 10 µM. It improves glucose tolerance and decreases fasting plasma insulin levels in a mouse model of diet-induced obesity when administered at a dose of 50 mg/kg per day.Formal Name: N,N-diethyl-4-[4-[[3-(1-piperidinyl)propyl]amino]-2-quinolinyl]-benzamide, dihydrochloride. CAS Number: 2310135-46-5. Synonyms: LMPTP Inhibitor I, MLS-0322825 Cmpd 23. Molecular Formula: C28H36N4O . 2HCl. Formula Weight: 517.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20mg/mL, DMSO: 10mg/mL, Ethanol: 15mg/mL, PBS (pH 7.2): 3mg/mL. lambdamax: 220, 268, 317, 345 nm. SMILES: O=C(N(CC)CC)C(C=C1)=CC=C1C2=CC(NCCCN3CCCCC3)=C(C=CC=C4)C4=N2.Cl.Cl. InChi Code: InChI=1S/C28H36N4O.2ClH/c1-3-32(4-2)28(33)23-15-13-22(14-16-23)26-21-27(24-11-6-7-12-25(24)30-26)29-17-10-20-31-18-8-5-9-19-31,,/h6-7,11-16,21H,3-5,8-10,17-20H2,1-2H3,(H,29,30),2*1H. InChi Key: YDTJMPCNLMSGEO-UHFFFAOYSA-N.
Keywords:
LMPTP Inhibitor I, MLS-0322825 Cmpd 23, N,N-diethyl-4-[4-[[3-(1-piperidinyl)propyl]amino]-2-quinolinyl]-benzamide
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