Leucomycin a5

Description: Leucomycin a5 is a metabolite from the leucomycin complex, which was originally isolated from S. kitasatoensis. It is active against a variety of Gram-positive and Gram-negative bacteria (MICs = 0.04-0.8 µg/ml) but not against K. pneumoniae, S. typhimurium, or E. coli with MICs ranging from 5 to >10 µg/ml. Leucomycin A5 is also active against penicillin-susceptible and -resistant S. pyogenes (MICs = 0.8 and 3.2 µg/ml, respectively) and S. faecalis (MIC = 0.8 µg/ml). Target: Others. Smiles: [H][C@@]1(C[C@@](C)(O)[C@@H](OC(=O)CCC)[C@H](C)O1)O[C@@H]1[C@@H](C)O[C@@]([H])(O[C@H]2[C@@H](CC=O)C[C@@H](C)[C@@H](O)\C=C\C=C\C[C@@H](C)OC(=O)C[C@@H](O)[C@@H]2OC)[C@H](O)[C@H]1N(C)C. References: Yamashita K, Kinoshita K. X-ray crystallographies of leucomycin A5 and rokitamycin monomethylacetal. J Antibiot (Tokyo). 1997 Nov,50(11):975-8. PubMed PMID: 9592575.