Leucinostatin A

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
Cay28190-500	500 µg		-		6 - 10 business days*		226.00€
Cay28190-2.5	2500 µg		-		6 - 10 business days*		1,015.00€

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Leucinostatin A is a fungal metabolite originally isolated from P. lilacinus with diverse... more

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Product information "Leucinostatin A"

Leucinostatin A is a fungal metabolite originally isolated from P. lilacinus with diverse biological activities. It is active against P. oryzae, B. cinera, P. chrysogenum, X. oryzae, S. cerevisiae, and C. albicans fungi and B. subtilis, S. aureus, S. lutea, and M. phlei bacteria in a disc assay. Leucinostatin A (0.1-1 µg/ml) reduces T cell activation induced by phorbol 12-myristate 13-acetate (TPA, Cay-10008014) or an anti-CD3 antibody in a concentration-dependent manner. It inhibits proliferation of DU145 prostate cancer cells co-cultured with PrSC stromal cells in vitro (IC50 = 0.045 µg/ml).CAS Number: 76600-38-9. Synonyms: P168. Molecular Formula: C62H111N11O13. Formula Weight: 1218.6. Purity: >85%. Formulation: (Request formulation change), A solid. Solubility: DMF: soluble, DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: CC(C)C[C@H](NC([C@H](CC(C)C)NC(C(C)(C)NC([C@H]([C@@H](C(C)C)O)NC([C@@H](NC([C@H]1N(C(/C=C/[C@@H](C)CC)=O)C[C@@H](C)C1)=O)C[C@H](C)C[C@H](O)CC(CC)=O)=O)=O)=O)=O)C(NC(C)(C)C(NC(C)(C)C(NCCC(N[C@@H](C)CN(C)C)=O)=O)=O)=O. InChi Code: InChI=1S/C62H111N11O13/c1-21-38(9)23-24-49(77)73-33-40(11)31-47(73)55(82)66-46(30-39(10)29-43(75)32-42(74)22-2)53(80)68-50(51(78)37(7)8)56(83)70-61(15,16)58(85)67-44(27-35(3)4)52(79)65-45(28-36(5)6)54(81)69-62(17,18)59(86)71-60(13,14)57(84)63-26-25-48(76)64-41(12)34-72(19)20/h23-24,35-41,43-47,50-51,75,78H,21-22,25-34H2,1-20H3,(H,63,84)(H,64,76)(H,65,79)(H,66,82)(H,67,85)(H,68,80)(H,69,81)(H,70,83)(H,71,86)/b24-23+/t38-,39+,40-,41-,43-,44-,45-,46-,47-,50-,51+/m0/s1. InChi Key: FOAIGCPESMNWQP-TXVCAPCZSA-N. Origin: Fungus/Paecilomyces sp..