Lercanidipine (hydrochloride)

Lercanidipine is a dihydropyridine L-type calcium channel blocker. It binds to rat brain and heart homogenates (Kis = 0.24-0.3 and 0.22 nM, respectively, in radioligand binding assays) and inhibits potassium-induced contraction of isolated rat aorta (IC50 = 1.3 nM). Lercanidipine reduces diastolic blood pressure (DBP) in normotensive and spontaneously hypertensive rats with ED25 values of 16.3 and 15.5 µg/kg, respectively. Formulations containing lercanidipine have been used in the treatment of hypertension.Formal Name: 3,5-pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-methyl ester, monohydrochloride. CAS Number: 132866-11-6. Molecular Formula: C36H41N3O6 . HCl. Formula Weight: 648.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 25mg/mL, DMF:PBS (pH 7.2) (1:2): 0.3mg/mL, DMSO: 15mg/mL, Ethanol: 2mg/mL. lambdamax: 239, 363 nm. SMILES: CC(NC(C)=C1C(OC(C)(C)CN(C)CCC(C2=CC=CC=C2)C3=CC=CC=C3)=O)=C(C(OC)=O)C1C4=CC([N+]([O-])=O)=CC=C4.Cl. InChi Code: InChI=1S/C36H41N3O6.ClH/c1-24-31(34(40)44-6)33(28-18-13-19-29(22-28)39(42)43)32(25(2)37-24)35(41)45-36(3,4)23-38(5)21-20-30(26-14-9-7-10-15-26)27-16-11-8-12-17-27,/h7-19,22,30,33,37H,20-21,23H2,1-6H3,1H. InChi Key: WMFYOYKPJLRMJI-UHFFFAOYSA-N.