Leptomycin B
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Leptomycin B (LMB) is a potent inhibitor of the nuclear export of proteins and is a... more
Product information "Leptomycin B"
Description: Leptomycin B (LMB) is a potent inhibitor of the nuclear export of proteins and is a potent antifungal antibiotic blocking the eukaryotic cell cycle. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Target: Antibiotic, Antifungal, CRM1. Smiles: CC\C(\C=C\[C@H]1OC(=O)C=C[C@@H]1C)=C\[C@H](C)C\C=C\C(\C)=C\[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)C\C(C)=C\C(O)=O. References: Kudo N, et al. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region. Proc Natl Acad Sci U S A. 1999 Aug 3,96(16):9112-7.
| Keywords: | LMB, CI 940 |
| Supplier: | TargetMol |
| Supplier-Nr: | T15735 |
Properties
| Application: | Nuclear export blocker |
| MW: | 540.73 D |
| Formula: | C33H48O6 |
Database Information
| CAS : | 87081-35-4| Matching products |
| KEGG ID : | K14290 | Matching products |
Handling & Safety
| Storage: | +4°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H225, H301, H311, H331, H370 |
| P Phrases: | P210, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P312, P321, P330, P301+P310, P302+P352, P303+P361+P353, P304+P340, P308+P311, P361+P364, P370+P378, P405, P403+P233, P403+P235, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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