LEI-106

In humans, two forms of diacylglycerol lipase, DAGLalpha and DAGLbeta, generate the endocannabinoid 2-arachidonoyl glycerol (2-AG, Cay-62160) by attacking DAG at the sn-1 position. LEI-106 is a potent in vitro inhibitor of sn-1 DAGLalpha (IC50 = 18 nM). It blocks the hydrolysis of sn-1-oleoyl-2-AG, the natural substrate of DAGLalpha, with a Ki value of 0.7 µM. LEI-106 inhibits the hydrolysis of 2-AG by the monoacylglycerol lipase ABHD6 in mouse brain membrane homogenates and in HEK293T cell membrane preparations (Ki = 0.8 µM).Formal Name: N-[(3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-6-yl)sulfonyl]-N-[(4-phenoxyphenyl)methyl]-glycine. CAS Number: 1620582-23-1. Molecular Formula: C26H27NO6S. Formula Weight: 481.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml, DMSO: 30 mg/ml, Ethanol: 0.1 mg/ml. lambdamax: 245 nm. SMILES: OC(CN(S(C1=CC=C(OC(C)(C)CC2)C2=C1)(=O)=O)CC(C=C3)=CC=C3OC4=CC=CC=C4)=O. InChi Code: InChI=1S/C26H27NO6S/c1-26(2)15-14-20-16-23(12-13-24(20)33-26)34(30,31)27(18-25(28)29)17-19-8-10-22(11-9-19)32-21-6-4-3-5-7-21/h3-13,16H,14-15,17-18H2,1-2H3,(H,28,29). InChi Key: FOEGBOXMDBPYEV-UHFFFAOYSA-N.