LDN-192960 (hydrochloride)

LDN-192960 is an inhibitor of haspin protein kinase and dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (DYRK2) with IC50 values of 10 and 48 nM, respectively. It is selective for haspin and DYRK2 over TRKB, CLK1, DYRK1A, DYRK3, ROS, HIPK1, HIPK2, PIM-1, and PIM-2 kinases (IC50s = 720-91,000 nM).Formal Name: 3-[(2,7-dimethoxy-9-acridinyl)thio]-1-propanamine, dihydrochloride. CAS Number: 2309172-48-1. Molecular Formula: C18H20N2O2S . 2HCl. Formula Weight: 401.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 33 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 264 nm. SMILES: COC1=CC2=C(SCCCN)C3=CC(OC)=CC=C3N=C2C=C1.Cl.Cl. InChi Code: InChI=1S/C18H20N2O2S.2ClH/c1-21-12-4-6-16-14(10-12)18(23-9-3-8-19)15-11-13(22-2)5-7-17(15)20-16,,/h4-7,10-11H,3,8-9,19H2,1-2H3,2*1H. InChi Key: FNHCUCJBABESJB-UHFFFAOYSA-N.