LB244

LB244 is an irreversible STING antagonist. It binds to STING in a cell-free assay and inhibits STING activation induced by the STING agonist diABZI in cells (EC50 = 0.8 nM). LB244 (1 µM) inhibits diABZI-induced STING oligomerization and phosphorylation of IFN regulatory factor 3 (IRF3) and TANK-binding kinase 1 (TBK1) in primary mouse bone marrow-derived macrophages (BMDMs). In vivo, LB244 (5 mg/kg, i.p.) reduces diABZI-induced increases in serum IL-6 and IFN-beta levels in mice.Formal Name: (R)-N-(4-([1,1'-biphenyl]-4-carboxamido)-4-(1H-benzo[d]imidazol-2-yl)butyl)-5-nitrofuran-2-carboxamide. Molecular Formula: C29H25N5O5. Formula Weight: 523.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Soluble. SMILES: O=C(N[C@@H](C1=NC(C=CC=C2)=C2N1)CCCNC(C3=CC=C([N+]([O-])=O)O3)=O)C(C=C4)=CC=C4C5=CC=CC=C5. InChi Code: InChI=1S/C29H25N5O5/c35-28(21-14-12-20(13-15-21)19-7-2-1-3-8-19)33-24(27-31-22-9-4-5-10-23(22)32-27)11-6-18-30-29(36)25-16-17-26(39-25)34(37)38/h1-5,7-10,12-17,24H,6,11,18H2,(H,30,36)(H,31,32)(H,33,35)/t24-/m1/s1. InChi Key: PQGNTDYYMHGKPA-XMMPIXPASA-N.