LAU-159

LAU-159 is a positive allosteric modulator (PAM) of alpha6beta3gamma2 subunit-containing GABAA receptors. It selectively increases GABA-induced currents in X. laevis oocytes expressing alpha6beta3gamma2 over alpha1beta3gamma2, alpha2beta3gamma2, alpha3beta3gamma2, alpha4beta3gamma2, and alpha5beta3gamma2 subunit-containing receptors at 10 µM.Formal Name: 8-chloro-2,5-dihydro-2-(3-methoxyphenyl)-3H-pyrazolo[4,3-c]quinolin-3-one. CAS Number: 2055050-87-6. Molecular Formula: C17H12ClN3O2. Formula Weight: 325.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: Soluble. lambdamax: 220, 290 nm. SMILES: ClC1=CC2=C(C=C1)NC=C3C2=NN(C4=CC=CC(OC)=C4)C3=O. InChi Code: InChI=1S/C17H12ClN3O2/c1-23-12-4-2-3-11(8-12)21-17(22)14-9-19-15-6-5-10(18)7-13(15)16(14)20-21/h2-9,19H,1H3. InChi Key: WQYIIWQWPXNTAK-UHFFFAOYSA-N.