Lanifibranor

Lanifibranor is an agonist of peroxisome proliferator-activated receptors (PPARs) with EC50 values of 1,537, 866, and 206 nM for human recombinant PPARalpha, PPARbeta, and PPARgamma, respectively, for transactivation activity. It increases beta-oxidation in Huh-7 and C2C12 cells when used at concentrations of 1 and 3 µM, respectively, and increases the expression of the PPARgamma target genes adipocyte protein 2 (aP2) and adiponectin in adipocytes. Lanifibranor reduces plasma glucose and triglyceride levels in a db/db mouse model of type 2 diabetes when administered at doses of 10 and 30 mg/kg for five days. It also increases plasma adiponectin levels and decreases collagen deposition in a carbon tetrachloride-induced mouse model of non-alcoholic steatohepatitis (NASH).Formal Name: 1-(6-benzothiazolylsulfonyl)-5-chloro-1H-indole-2-butanoic acid. CAS Number: 927961-18-0. Synonyms: IVA337. Molecular Formula: C19H15ClN2O4S2. Formula Weight: 434.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, DMSO:PBS(pH 7.2) (1:4): 0.2 mg/ml, Ethanol: 0.2 mg/ml. lambdamax: 223, 262 nm. SMILES: O=S(C1=CC(SC=N2)=C2C=C1)(N3C(CCCC(O)=O)=CC4=C3C=CC(Cl)=C4)=O. InChi Code: InChI=1S/C19H15ClN2O4S2/c20-13-4-7-17-12(8-13)9-14(2-1-3-19(23)24)22(17)28(25,26)15-5-6-16-18(10-15)27-11-21-16/h4-11H,1-3H2,(H,23,24). InChi Key: OQDQIFQRNZIEEJ-UHFFFAOYSA-N.