Lamotrigine

Lamotrigine is an anticonvulsant. It inhibits voltage-gated sodium channels (Nav) in HEK293 cells expressing recombinant human Nav1.2, Nav1.5, or Nav1.8 (IC50s = 10, 62, and 96 µM, respectively), as well as high voltage-activated calcium currents in isolated rat cortical neurons (IC50 = 12.3 µM), an effect that can be reversed by the N-type calcium channel blocker omega-conotoxin GVIA (Cay-24114) and P-type calcium channel blocker omega-agatoxin IVA (Cay-21605). Lamotrigine protects against seizures induced by maximal electroshock (MES) in mice and rats (ED50s = 10.1 and 7.4 µmol/kg, respectively). It also decreases mechanical allodynia in a rat model of neuropathic pain induced by spinal nerve ligation (ED50 = 47 µmol/kg). Formulations containing lamotrigine have been used in the treatment of epilepsy and bipolar disorder.Formal Name: 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine. CAS Number: 84057-84-1. Synonyms: BW 430C, LTG. Molecular Formula: C9H7Cl2N5. Formula Weight: 256.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 2 mg/ml. SMILES: ClC1=C(Cl)C(C2=NN=C(N)N=C2N)=CC=C1. InChi Code: InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16). InChi Key: PYZRQGJRPPTADH-UHFFFAOYSA-N.