Lactisole

Lactisole is an antagonist of sweet taste receptors, reducing both sweetness intensity and persistence. It blocks the activation of the sweet taste receptor T1R3 by natural and synthetic sweeteners and increases the inhibition of T1R2 by umami compounds. Lactisole can be used to explore the roles of these receptors in diverse pathways, including glucose-induced insulin secretion in pancreatic beta-cells and the secretion of glucagon-like peptides by enteroendocrine L-cells.Formal Name: 2-(4-methoxyphenoxy)-propanoic acid, monosodium salt. CAS Number: 150436-68-3. Synonyms: na-PMP. Molecular Formula: C10H11O4 . Na. Formula Weight: 218.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 10 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 226, 289 nm. SMILES: COC1=CC=C(OC(C)C([O-])=O)C=C1.[Na+]. InChi Code: InChI=1S/C10H12O4.Na/c1-7(10(11)12)14-9-5-3-8(13-2)4-6-9,/h3-7H,1-2H3,(H,11,12),/q,+1/p-1. InChi Key: SKORRGYRKQDXRS-UHFFFAOYSA-M.