Lactacystin

Lactacystin
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay70980-50 50 µg -

6 - 10 business days*

48.00€
Cay70980-100 100 µg -

6 - 10 business days*

78.00€
Cay70980-500 500 µg -

6 - 10 business days*

241.00€
Cay70980-1 1 mg -

6 - 10 business days*

434.00€
 
Lactacystin is a microbial metabolite isolated from Streptomyces that is now widely used as a... more
Product information "Lactacystin"
Lactacystin is a microbial metabolite isolated from Streptomyces that is now widely used as a selective inhibitor of the 20S proteasome. Lactacystin was first characterized by its ability to induce differentiation and inhibit cell cycle progression in several tumor cell lines. At concentrations from 2 to 10 µM, lactacystin induces the outgrowth of neurites in the neuroblastoma cell line Neuro2a. Lactacystin irreversibly alkylates subunit X of the 20S proteasome. The concomitant inhibition of proteasome peptidase activity results in the accumulation of a variety of ubiquitinated proteins which would normally undergo rapid degradation. Thus, the effects of lactacystin are pleiotropic and depend substantially on the expression pattern of signalling proteins within the treated cell.Formal Name: 3S-hydroxy-2R-(1-hydroxy-2-methylpropyl)-4R-methyl-5-oxo-2-pyrrolidinecarboxylate-N-acetyl-L-cysteine. CAS Number: 133343-34-7. Molecular Formula: C15H24N2O7S. Formula Weight: 376.4. Purity: >98%. Formulation: (Request formulation change), A clear film. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 1 mg/ml, Methanol: 1 mg/ml, PBS (7.2): 2 mg/ml, Water: 10 mg/ml. SMILES: O=C(SC[C@@H](C(O)=O)N(C(C)=O)[H])[C@@]1(N([H])C([C@H](C)[C@@H]1O)=O)[C@H](C(C)C)O. InChi Code: InChI=1S/C15H24N2O7S/c1-6(2)10(19)15(11(20)7(3)12(21)17-15)14(24)25-5-9(13(22)23)16-8(4)18/h6-7,9-11,19-20H,5H2,1-4H3,(H,16,18)(H,17,21)(H,22,23)/t7-,9?,10+,11+,15-/m1/s1. InChi Key: DAQAKHDKYAWHCG-MJZHQVMOSA-N.
Keywords: 3S-hydroxy-2R-(1-hydroxy-2-methylpropyl)-4R-methyl-5-oxo-2-pyrrolidinecarboxylate-N-acetyl-L-cysteine
Supplier: Cayman Chemical
Supplier-Nr: 70980

Properties

Application: 20S proteasome inhibitor
MW: 376.4 D
Formula: C15H24N2O7S
Purity: >98%
Format: Solid

Database Information

CAS : 133343-34-7| Matching products
KEGG ID : K02737 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Lactacystin"
Write a review
or to review a product.
Viewed