L6H21

L6H21 is an inhibitor of myeloid differentiation 2 (MD-2), also known as lymphocyte antigen 96 (LY96). It binds to MD-2 (Kd = 33.3 µM in a cell-free assay) and inhibits the protein-protein interaction between MD-2 and toll-like receptor 4 (TLR4) in LPS-stimulated ECV304 cells. L6H21 (10 µM) decreases the migration of LPS-stimulated HCT116 colon cancer cells. It inhibits LPS-induced increases in the production of TNF-alpha and IL-6 in mouse primary macrophages (IC50s = 6.17 and 7.72 µM, respectively), as well as increases survival in a mouse model of LPS-induced sepsis. L6H21 (40 mg/kg) increases cardiac levels of glutathione peroxidase 4 (GPX4) and decreases cardiac mitochondrial reactive oxygen species (ROS) in rats fed a high-fat diet.Formal Name: (2E)-3-(2,3-dimethoxyphenyl)-1-(4-methoxyphenyl)-2-propen-1-one. CAS Number: 24533-47-9. Molecular Formula: C18H18O4. Formula Weight: 298.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml, DMSO: 5 mg/ml. lambdamax: 320 nm. SMILES: COC1=C(C=CC=C1OC)/C=C/C(C2=CC=C(C=C2)OC)=O. InChi Code: InChI=1S/C18H18O4/c1-20-15-10-7-13(8-11-15)16(19)12-9-14-5-4-6-17(21-2)18(14)22-3/h4-12H,1-3H3/b12-9+. InChi Key: IECVLMVZGCYCSZ-FMIVXFBMSA-N.