L-Phenylalanine

L-Phenylalanine is an essential amino acid. Blood and brain levels of L-phenylalanine are increased and associated with progressive cognitive impairments, seizures, motor deficits, and autism in patients with phenylketonuria, an inborn error of metabolism characterized by mutations in the gene encoding phenylalanine hydroxylase (PAH). L-Phenylalanine inhibits NMDA-induced currents in primary rat hippocampal neurons (IC50 = 1.71 mM). It also assembles into fibrils in vitro that are cytotoxic to PC12 and CHO cells when used at concentrations ranging from 1.16 to 15 mM.CAS Number: 63-91-2. Synonyms: NSC 79477, (-)-Phenylalanine. Molecular Formula: C9H11NO2. Formula Weight: 165.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 5 mg/ml. SMILES: OC([C@@H](N)CC1=CC=CC=C1)=O. InChi Code: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1. InChi Key: COLNVLDHVKWLRT-QMMMGPOBSA-N.