L-Norvaline

L-Norvaline is a non-proteinogenic amino acid, an isomer of valine, and an inhibitor of arginase and p70 ribosomal S6 kinase 1 (p70S6K1) kinase. It inhibits arginase-mediated urea production in J774A.1 macrophage lysates when used at a concentration of 10 mM and TNF-alpha-induced p70S6K1 activation in human umbilical vein endothelial cells (HUVECs) at 20 mM. L-Norvaline reduces microgliosis and the level of amyloid-beta fibrils in the hippocampus, as well as improves learning and memory in the Morris water maze in the 3xTg mouse model of Alzheimer's disease.CAS Number: 6600-40-4. Synonyms: alpha-L-Aminopentanoic Acid, L-Nva, NSC 203786. Molecular Formula: C5H11NO2. Formula Weight: 117.1. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: PBS (pH 7.2): 10 mg/ml. SMILES: CCC[C@H](N)C(O)=O. InChi Code: InChI=1S/C5H11NO2/c1-2-3-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1. InChi Key: SNDPXSYFESPGGJ-BYPYZUCNSA-N.