L-NIL (hydrochloride)

L-NIL is a relatively selective inhibitor of iNOS. It exhibits IC50 values of 0.4-3.3 µM for iNOS as opposed to 8-38 and 17-92 µM for eNOS and nNOS, respectively. L-NIL effectively inhibits iNOS both in vitro and in vivo. L-NIL has been used to demonstrate a critical role for iNOS in the immune response to infection by the protozoan L. major.Formal Name: N6-(1-iminoethyl)-L-lysine, dihydrochloride. CAS Number: 159190-45-1. Molecular Formula: C8H17N3O2 . 2HCl. Formula Weight: 260.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMSO: 15 mg/ml, Ethanol: 1 mg/ml, PBS: 30 mg/ml, Water: 50 mg/ml. SMILES: C/C(N([H])CCCC[C@H](N)C(O)=O)=N/[H].Cl.Cl. InChi Code: InChI=1S/C8H17N3O2.2ClH/c1-6(9)11-5-3-2-4-7(10)8(12)13,,/h7H,2-5,10H2,1H3,(H2,9,11)(H,12,13),2*1H. InChi Key: OQIBCXRAFAHXMM-UHFFFAOYSA-N.