L-(-)-alpha-Methyldopa

L-(-)-alpha-Methyldopa is a dopamine (DOPA) decarboxylase inhibitor (ED50 = 21.8 mg/kg) and has antihypertensive activity in vitro and in vivo. L-(-)-alpha-Methyldopa enters the CNS and is metabolized to form alpha-methylnorepinephrine which acts as an agonist at alpha2-adrenergic receptors. Formulations containing L-(-)-alpha-methyldopa are used to lower blood pressure. L-(-)-alpha-Methyldopa also improves trophoblast and endothelial cellular interactions in vitro.Formal Name: 3-hydroxy-alpha-methyl-L-tyrosine. CAS Number: 555-30-6. Synonyms: Methyldopa, MK-351, NSC 169916. Molecular Formula: C10H13NO4. Formula Weight: 211.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Water: sparingly soluble. lambdamax: 224, 284 nm. SMILES: OC1=C(O)C=CC(C[C@](C)(N)C(O)=O)=C1. InChi Code: InChI=1S/C10H13NO4/c1-10(11,9(14)15)5-6-2-3-7(12)8(13)4-6/h2-4,12-13H,5,11H2,1H3,(H,14,15)/t10-/m0/s1. InChi Key: CJCSPKMFHVPWAR-JTQLQIEISA-N.