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Product information "L-alpha-Hydroxyglutaric Acid (sodium salt)"
L-alpha-Hydroxyglutaric acid (L-2-HG) is an alpha-hydroxy acid. It is metabolized to 2-oxoglutarate (alpha-ketoglutarate) by L-2-hydroxyglutarate dehydrogenase, and mutations in this enzyme lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased L-2-HG levels. L-2-HG is structurally similar to alpha-ketoglutarate and competitively inhibits alpha-ketoglutarate-dependent dioxygenases, including several involved in histone lysine and DNA demethylation.Formal Name: 2S-hydroxy-pentanedioic acid, disodium salt. CAS Number: 63512-50-5. Synonyms: FA 5:1,O3, L-2-HG, L-2-Hydroxyglutarate, L-2-Hydroxyglutaric Acid, (S)-2-Hydroxypentanedioic Acid. Molecular Formula: C5H8O5 . 2Na. Formula Weight: 194.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. SMILES: OC(CC[C@H](O)C(O)=O)=O.[Na].[Na]. InChi Code: InChI=1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8,,/h3,6H,1-2H2,(H,7,8)(H,9,10),,/t3-,,/m0../s1. InChi Key: UVBKSRZGVBRXSI-QTNFYWBSSA-N.
Keywords:
(S)-2-Hydroxypentanedioic Acid, L-2-HG, L-2-Hydroxyglutarate, L-2-Hydroxyglutaric Acid, 2S-hydroxy-pentanedioic acid, disodium salt
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