L-732,138

L-732,138 is a neurokinin-1 (NK1) receptor antagonist (IC50 = 1.6 nM in CHO cells expressing the human receptor). It is selective for NK1 over NK2 and NK3 receptors (IC50s = >5,000 nM for both). L-732,138 inhibits the growth of COLO 858, MEL HO, and COLO 679 melanoma cells (IC50s = 44.6, 76.3, and 64.2 µM, respectively), as well as induces apoptosis in these cell lines. It inhibits plasma extravasation induced by substance P (Cay-24035) in guinea pigs (ID50 = 8 mg/kg, i.p.). L-732,138 attenuates mechanical allodynia and cold hyperalgesia in a rat model of neuropathic pain induce by chronic constriction injury of the sciatic nerve.Formal Name: N-acetyl-L-tryptophan [3,5-bis(trifluoromethyl)phenyl]methyl ester. CAS Number: 148451-96-1. Molecular Formula: C22H18F6N2O3. Formula Weight: 472.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml. lambdamax: 221 nm. SMILES: CC(N[C@@H](CC1=CNC2=C1C=CC=C2)C(OCC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=O)=O. InChi Code: InChI=1S/C22H18F6N2O3/c1-12(31)30-19(8-14-10-29-18-5-3-2-4-17(14)18)20(32)33-11-13-6-15(21(23,24)25)9-16(7-13)22(26,27)28/h2-7,9-10,19,29H,8,11H2,1H3,(H,30,31)/t19-/m0/s1. InChi Key: BYYQYXVAWXAYQC-IBGZPJMESA-N.