L-655,708

L-655,708 is a ligand for alpha5 subunit-containing GABAA receptors that has nootropic activity. It selectively binds to alpha5 subunit-containing GABAA receptors over alpha1, alpha2, or alpha3 subunit-containing receptors (Kis = 1, 70, 48, and 31 nM, respectively, for recombinant human receptors). L-655,708 (10 nM) increases the amplitude of extracellular post-synaptic potentials (EPSPs) in mouse hippocampal slices. In vivo, L-655,708 (1.5 mg/animal) decreases the latency to find the platform and increases time spent in the target quadrant in the Morris water maze in mice.Formal Name: (13aS)-11,12,13,13a-tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, ethyl ester. CAS Number: 130477-52-0. Molecular Formula: C18H19N3O4. Formula Weight: 341.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 2 mg/mL, DMF:PBS (pH 7.2) (1:20): Slightly soluble, DMSO: 1mg/mL. lambdamax: 248 nm. SMILES: COC1=CC(C(N2[C@@]3([H])CCC2)=O)=C(C=C1)N4C3=C(C(OCC)=O)N=C4. InChi Code: InChI=1S/C18H19N3O4/c1-3-25-18(23)15-16-14-5-4-8-20(14)17(22)12-9-11(24-2)6-7-13(12)21(16)10-19-15/h6-7,9-10,14H,3-5,8H2,1-2H3/t14-/m0/s1. InChi Key: YKYOQIXTECBVBB-AWEZNQCLSA-N.