KYP-2047

KYP-2047 is an inhibitor of prolyl endopeptidase (Ki = 0.02 nM for the porcine enzyme). It inhibits hydrogen peroxide-induced aggregation of alpha-synuclein in SH-SY5Y cells expressing wild-type, alpha-synucleinA30P, or alpha-synucleinA53T in in vitro models of Parkinson's disease when used at a concentration of 1 µM. KYP-2047 (10 µM) decreases lipid peroxidation and the production of reactive oxygen species (ROS) induced by palmitic acid (Cay-10006627) in HepG2 cells. It decreases ileal and pulmonary edema and pulmonary fibrosis in a mouse model of acute lung injury induced by intestinal ischemia-reperfusion when administered at a dose of 2.5 mg/kg. KYP-2047 (2.5 mg/kg) reduces tumor volume and intratumoral levels of Vegf and Cd34, markers of angiogenesis, in a U87 glioblastoma mouse xenograft model.Formal Name: (2S)-1-[[(2S)-1-(1-oxo-4-phenylbutyl)-2-pyrrolidinyl]carbonyl]-2-pyrrolidinecarbonitrile. CAS Number: 796874-99-2. Molecular Formula: C20H25N3O2. Formula Weight: 339.4. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Acetonitrile: Soluble, DMSO: Soluble, Methanol: Soluble. SMILES: O=C(N1CCC[C@H]1C(N2CCC[C@H]2C#N)=O)CCCC3=CC=CC=C3. InChi Code: InChI=1S/C20H25N3O2/c21-15-17-10-5-13-22(17)20(25)18-11-6-14-23(18)19(24)12-4-9-16-7-2-1-3-8-16/h1-3,7-8,17-18H,4-6,9-14H2/t17-,18-/m0/s1. InChi Key: SPXFAUXQZWJGCJ-ROUUACIJSA-N.