Kynurenic Acid-d5

Kynurenic acid-d5 is intended for use as an internal standard for the quantification of kynurenic acid (Cay-16792) by GC- or LC-MS. Kynurenic acid is an active metabolite of tryptophan (Cay-29600, Cay-31210). It is formed from tryptophan via a kynurenine (Cay-11305) intermediate by kynurenine aminotransferases (KATs). Kynurenic acid is an antagonist of the NMDA and AMPA receptors as well as alpha7 nicotinic acetylcholine receptors (nAChRs, EC50s = 235, 101, and 7 µM, respectively). It is also an agonist of the aryl hydrocarbon receptor (AhR) and G protein-coupled receptor 35 (GPR35, EC50s = 1.4 and 39 µM, respectively). It prevents lesioned hemisphere weight loss in a neonatal rat model of cerebral hypoxic-ischemia induced by carotid artery ligation when administered at a dose of 300 mg/kg. Kynurenic acid (1 and 5 mg/ml) is protective against rhabdomere neurodegeneration in the eye in an Htt93Q transgenic Drosophila model of Huntington's disease. Levels of kynurenic acid in cerebrospinal fluid are increased in patients with schizophrenia.Formal Name: 4-hydroxy-2-quinoline-3,5,6,7,8-d5-carboxylic acid. CAS Number: 350820-13-2. Molecular Formula: C10H2D5NO3. Formula Weight: 194.2. Purity: >99% deuterated forms (d1-d5). Formulation: (Request formulation change), A solid. Solubility: Dichloromethane: slightly, DMSO: slightly. SMILES: OC1=C([2H])C(C(O)=O)=NC2=C1C([2H])=C([2H])C([2H])=C2[2H]. InChi Code: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/i1D,2D,3D,4D,5D. InChi Key: HCZHHEIFKROPDY-RALIUCGRSA-N.