KSQ-4279

KSQ-4279 is an inhibitor of ubiquitin-specific protease 1 (USP1, IC50 = 21.1 nM). It reduces the viability of H1299 non-small cell lung cancer (NSCLC) cells when used at a concentration of 500 nM. KSQ-4279 (1 µM) induces cell cycle arrest at the S phase in MDA-MB-436 breast cancer cells.Formal Name: 6-(4-cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[[4-[1-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-2-yl]phenyl]methyl]-1H-pyrazolo[3,4-d]pyrimidine. CAS Number: 2446480-97-1. Synonyms: Ubiquitin-specific Protease 1 Inhibitor 1, USP1-IN-1, USP1 Inhibitor 1. Molecular Formula: C27H25F3N8O. Formula Weight: 534.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly soluble: 0.1-1 mg/ml, DMSO: Sparingly soluble: 1-10 mg/ml, Ethanol: Sparingly soluble: 1-10 mg/ml. SMILES: COC1=NC=NC(C2CC2)=C1C3=NC=C(C=NN4CC5=CC=C(C6=NC(C(F)(F)F)=CN6C(C)C)C=C5)C4=N3. InChi Code: InChI=1S/C27H25F3N8O/c1-15(2)37-13-20(27(28,29)30)35-24(37)18-6-4-16(5-7-18)12-38-25-19(11-34-38)10-31-23(36-25)21-22(17-8-9-17)32-14-33-26(21)39-3/h4-7,10-11,13-15,17H,8-9,12H2,1-3H3. InChi Key: KCBWAFJCKVKYHO-UHFFFAOYSA-N.