KRN 633

KRN 633 is an ATP-competitive inhibitor of VEGFR kinase activity (IC50s = 170, 160, and 125 nM for VEGFR1, 2, and 3, respectively). At higher concentrations KRN 633 inhibits PDGFR-alpha and c-KIT with IC50 values of 0.97 and 4.3 µM, respectively, and is inactive towards a panel of 17 additional kinases. KRN 633 suppresses VEGF-dependent activation of MAPK and cell proliferation and demonstrates antitumor and antiangiogenic activity by inhibiting vessel formation and vascular permeability in human tumor xenograft models.Formal Name: N-[2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-propyl-urea. CAS Number: 286370-15-8. Molecular Formula: C20H21ClN4O4. Formula Weight: 416.9. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml, DMSO: 0.3 mg/ml. lambdamax: 210, 242, 320 nm. SMILES: COC(C(OC)=C1)=CC2=C1C(OC3=CC(Cl)=C(NC(NCCC)=O)C=C3)=NC=N2. InChi Code: InChI=1S/C20H21ClN4O4/c1-4-7-22-20(26)25-15-6-5-12(8-14(15)21)29-19-13-9-17(27-2)18(28-3)10-16(13)23-11-24-19/h5-6,8-11H,4,7H2,1-3H3,(H2,22,25,26). InChi Key: VPBYZLCHOKSGRX-UHFFFAOYSA-N.