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KM 11060 is a small molecule that corrects the processing of cystic fibrosis transmembrane conductance regulator (CFTR) proteins bearing the F508 deletion (F508del) mutation carried by 90% of cystic fibrosis patients. It increases cell surface expression and restores chloride transport function of F508del-CFTRs in BHK cells at a concentration of 10 µM. KM 11060 restores F508del-CFTR function, as measured by cAMP-stimulated iodide efflux, in CFBE41o- human airway epithelial cells at a concentration of 10 nM. It also restores the secretory response to approximately 51% of wild-type levels ex vivo in ileum isolated from F508del-CFTR mice at a concentration of 20 µM.Formal Name: 7-chloro-4-[4-[(4-chlorophenyl)sulfonyl]-1-piperazinyl]-quinoline. CAS Number: 774549-97-2. Molecular Formula: C19H17Cl2N3O2S. Formula Weight: 422.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 2 mg/ml, Ethanol: 0.5 mg/ml. lambdamax: 201, 227, 321 nm. SMILES: ClC1=CC=C(S(N2CCN(C3=CC=NC4=C3C=CC(Cl)=C4)CC2)(=O)=O)C=C1. InChi Code: InChI=1S/C19H17Cl2N3O2S/c20-14-1-4-16(5-2-14)27(25,26)24-11-9-23(10-12-24)19-7-8-22-18-13-15(21)3-6-17(18)19/h1-8,13H,9-12H2. InChi Key: GIEHIZKCIZLXLF-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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