KJ Pyr 9

KJ Pyr 9 is a cell-permeable inhibitor of c-Myc (Kd = 6.5 nM) that interferes with Myc-Max complex formation in cells. It preferentially blocks the proliferation of c-Myc-overexpressing cells, reducing Myc-driven gene expression. KJ Pyr 9 also potently blocks cell growth directed by overexpression of v-Myc, while less effectively blocking N-Myc- and L-Myc-dependent proliferation. It is effective in vivo, reducing the growth of breast cancer MDA-MB-231 xenografts in mice.Formal Name: 4-[2-(2-furanyl)-6-(4-nitrophenyl)-4-pyridinyl]-benzamide. CAS Number: 581073-80-5. Molecular Formula: C22H15N3O4. Formula Weight: 385.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS(pH7.2) (1:2): 0.3 mg/ml, DMSO: 20 mg/ml. lambdamax: 280, 345 nm. SMILES: NC(C(C=C1)=CC=C1C2=CC(C3=CC=CO3)=NC(C4=CC=C([N+]([O-])=O)C=C4)=C2)=O. InChi Code: InChI=1S/C22H15N3O4/c23-22(26)16-5-3-14(4-6-16)17-12-19(15-7-9-18(10-8-15)25(27)28)24-20(13-17)21-2-1-11-29-21/h1-13H,(H2,23,26). InChi Key: GTTDVYCKFQYVNN-UHFFFAOYSA-N.