Kevetrin (hydrochloride)

Kevetrin is an activator of p53. It increases levels of activated p53 and expression of p21 in A549 cells and decreases expression of the transcription factor E2F1 in a variety of cell lines. Kevetrin decreases cell viability in a panel of cancer cell lines with a mean IC50 value of 0.49 µM. It reduces tumor growth in MDA-MB-231, HT-29, PC3, HCT15, A549, NCI-H1975, CRL-1619, LNCaP, MIA PaCa, and SCC-5 mouse xenograft models when administered at a dose of 200 mg/kg.Formal Name: carbamimidothioic acid, 3-cyanopropyl ester, monohydrochloride. CAS Number: 66592-89-0. Synonyms: 4-Isothioureidobutyronitrile, NSC 525990. Molecular Formula: C5H9N3S . HCl. Formula Weight: 179.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. SMILES: NC(SCCCC#N)=N.Cl. InChi Code: InChI=1S/C5H9N3S.ClH/c6-3-1-2-4-9-5(7)8,/h1-2,4H2,(H3,7,8),1H. InChi Key: NCXJZJFDQMKRKM-UHFFFAOYSA-N.