Ketorolac (tromethamine salt)

Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) and a non-selective COX inhibitor (IC50 = 20 nM for both COX-1 and COX-2). It prevents increases in paw swelling, increases paw withdrawal latency in a hot-plate test, and decreases prostaglandin E2 (PGE2) levels in paw tissue in a mouse model of carrageenan-induced inflammation when administered at a dose of 30 mg/kg. Ketorolac is a racemic mixture containing the active (S)-ketorolac (Cay-11348) and inactive (R)-ketorolac enantiomers. Formulations containing ketorolac have been used to manage postoperative pain and as ophthalmic solutions to treat ocular pain and inflammation.Formal Name: (±)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid, tris(hydroxymethyl)aminomethane salt. CAS Number: 74103-07-4. Synonyms: Toradol. Molecular Formula: C15H12NO3 . C4H12NO3. Formula Weight: 376.4. Purity: >99%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 7 mg/ml, PBS pH 7.2: 26 mg/ml. lambdamax: 243, 317 nm. SMILES: O=C(C1=CC=C2N1CCC2C([O-])=O)C3=CC=CC=C3.[NH3+]C(CO)(CO)CO. InChi Code: InChI=1S/C15H13NO3.C4H11NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13,5-4(1-6,2-7)3-8/h1-7,11H,8-9H2,(H,18,19),6-8H,1-3,5H2. InChi Key: BWHLPLXXIDYSNW-UHFFFAOYSA-N.