K6PC-5

K6PC-5 is a sphingosine kinase 1 (SPHK1) activator. It activates SPHK1 in F9-12 teratocarcinoma cell lysates and isolated murine blood in a concentration-dependent manner. K6PC-5 (25 and 50 µM) induces calcium oscillations in HaCaT keratinocytes. It inhibits cell death induced by oxygen-glucose deprivation/reoxygenation in SH-SY5Y neuroblastoma cells when used at a concentration of 10 µM. Topical administration of K6PC-5 (1%) increases stratum corneum integrity and corneodesmosome density in a mouse model of photoaging induced by long-term exposure to ultraviolet A (UVA) and UVB radiation.Formal Name: 2-hexyl-N-[2-hydroxy-1-(hydroxymethyl)ethyl]-3-oxo-decanamide. CAS Number: 756875-51-1. Molecular Formula: C19H37NO4. Formula Weight: 343.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 30 mg/ml. SMILES: O=C(C(CCCCCC)C(CCCCCCC)=O)NC(CO)CO. InChi Code: InChI=1S/C19H37NO4/c1-3-5-7-9-11-13-18(23)17(12-10-8-6-4-2)19(24)20-16(14-21)15-22/h16-17,21-22H,3-15H2,1-2H3,(H,20,24). InChi Key: CGYVFCHCRBGGJG-UHFFFAOYSA-N.