K03861

K03861 is an inhibitor of cyclin-dependent kinase 2 (Cdk2). It binds to wild-type Cdk2, Cdk2C118L, Cdk2A144C, and Cdk2C118L/A144C (Kds = 50, 18.6, 15.4, and 9.7 nM, respectively). K03861 selectively inhibits the proliferation of IL-3-stimulated Ba/F3 cells expressing an FMS-related tyrosine kinase 3 bearing internal-tandem duplication (FLT3-ITD) over wild-type Ba/F3 cells (IC50s = ~0.001 and > 0.1 µM, respectively). It inhibits human cytomegalovirus replication in primary human monocyte-derived macrophages (IC50 = 1.028 µM). K03861 (10 µM) inhibits spindle organization and chromosome alignment in meiosis I and prevents egg activation in isolated mouse oocytes.Formal Name: N-[4-[(2-amino-4-pyrimidinyl)oxy]phenyl]-N'-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-urea. CAS Number: 853299-07-7. Synonyms: AUZ454. Molecular Formula: C24H26F3N7O2. Formula Weight: 501.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble: >10 mg/ml, Ethanol: Soluble: >10 mg/ml. SMILES: CN1CCN(CC2=C(C(F)(F)F)C=C(NC(NC3=CC=C(OC4=NC(N)=NC=C4)C=C3)=O)C=C2)CC1. InChi Code: InChI=1S/C24H26F3N7O2/c1-33-10-12-34(13-11-33)15-16-2-3-18(14-20(16)24(25,26)27)31-23(35)30-17-4-6-19(7-5-17)36-21-8-9-29-22(28)32-21/h2-9,14H,10-13,15H2,1H3,(H2,28,29,32)(H2,30,31,35). InChi Key: PWDLXPJQFNVTNL-UHFFFAOYSA-N.